NECAP2 - NECAP endocytosis associated 2 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55707

About NECAP2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,440,724-16,460,078 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 34.8), spleen (RPKM 33.6) and 25 other tissues.

Summary

This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

NECAP2 Products (3)

mRNA	Protein	Name
NM_001145277.2	NP_001138749.1	adaptin ear-binding coat-associated protein 2 isoform 2
NM_001145278.2	NP_001138750.1	adaptin ear-binding coat-associated protein 2 isoform 3
NM_018090.5	NP_060560.1	adaptin ear-binding coat-associated protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECAP2 Protein Structure

DUF1681

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
adaptin ear-binding coat-associated protein 2	adaptin-ear-binding coat-associated protein 2

NECAP2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NECAP2	Q9NVZ3	AP2B1	Homo sapiens	P63010	Anti Tag CoIP	33961781
Intra	NECAP2	Q9NVZ3	AP2B1	Homo sapiens	P63010	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECAP2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70922	NECAP2 Protein, Human (His)	Q9NVZ3 (M1-F263)	≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Lissencephaly 8	LIS8
Congenital Anomalies Of Kidney And Urinary Tract 1	CAKUT1 Renal Hypodysplasia, Nonsyndromic, 1 Rhdns1 Congenital Anomalies Of The Kidney And Urinary Tract 1 Non-Syndromic Renal Hypodysplasia 1 Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1
Spinocerebellar Ataxia, Autosomal Recessive 24	SCAR24 Autosomal Recessive Spinocerebellar Ataxia 24 Spinocerebellar Ataxia, Autosomal Recessive, 24 Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Schuurs-Hoeijmakers Syndrome	SHMS Pacs1-Related Syndrome Mrd17 Intellectual Disability-Craniofacial Dysmorphism-Cryptorchidism Syndrome Intellectual Developmental Disorder, Autosomal Dominant 17 Autosomal Dominant Intellectual Disability-17 Autosomal Dominant Mental Retardation 17 Pacs1 Syndrome Mental Retardation, Autosomal Dominant 17
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS09173	NECAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19517	Necap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26012	Necap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	NECAP2	VGNC	VGNC:31981
Rattus norvegicus	NECAP2	RGD	RGD:735063
Canis familiaris	NECAP2	VGNC	VGNC:43717
Macaca mulatta	NECAP2	VGNC	VGNC:75255
Mus musculus	NECAP2	MGD	MGI:1913397
Others	NECAP2	NCBI