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FASTKD5 - FAST kinase domains 5 Gene

Also Known as dJ1187M17.5

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 60493

About FASTKD5

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,146,519-3,159,865 (from NCBI)

This gene has 5 transcripts (splice variants), 147 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), adrenal (RPKM 8.0) and 25 other tissues.

Summary

Enables rRNA binding activity. Involved in mitochondrial RNA processing. Located in mitochondrial nucleoid and ribonucleoprotein granule. [provided by Alliance of Genome Resources, Apr 2022]

FASTKD5 Products (1)

mRNA	Protein	Name
NM_021826.5	NP_068598.1	FAST kinase domain-containing protein 5, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables rRNA binding	IDA IDA: Inferred from direct assay	25683715	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in mitochondrial RNA processing	IMP IMP: Inferred from mutant phenotype	25683715	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	25683715	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20869947	GOA
located in ribonucleoprotein granule	IDA IDA: Inferred from direct assay	25683715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FASTKD5 Protein Structure

FAST_1

FAST_2

RAP

0
200
400
600
764 a.a.

Protein Preferred Names	Protein Names
FAST kinase domain-containing protein 5, mitochondrial

FASTKD5 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	FASTKD5	Q7L8L6	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	FASTKD5	Q7L8L6	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	FASTKD5	Q7L8L6	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	FASTKD5	Q7L8L6	KCNH1	Homo sapiens	O95259	Y2H Array	25416956
Intra	FASTKD5	Q7L8L6	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	FASTKD5	Q7L8L6	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	FASTKD5	Q7L8L6	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	FASTKD5	Q7L8L6	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	FASTKD5	Q7L8L6	TRIM27	Homo sapiens	P14373	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Mitochondrial Dna Depletion Syndrome 4b	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Mngie Syndrome Thymidine Phosphorylase Deficiency MTDPS4B Mitochondrial Neurogastrointestinal Encephalopathy Disease Mngie Myoneurogastrointestinal Encephalopathy Syndrome Ogimd Oculogastrointestinal Muscular Dystrophy Polip Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related Mngie, Polg-Related Mepop Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction Mngie Disease Mitochondrial Dna Depletion Syndrome 4b Mngie Type Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related Mngie Polg-Related Mitochondrial Dna Depletion Syndrome, Type 4b Visceral Myopathy Familial External Ophthalmoplegia
Cardiomyopathy, Infantile Hypertrophic	Infantile Hypertrophic Cardiomyopathy CMHI

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04759	FASTKD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	FASTKD5	VGNC	VGNC:106736
Mus musculus	FASTKD5	MGD	MGI:2139469
Macaca mulatta	FASTKD5	VGNC	VGNC:84767
Rattus norvegicus	FASTKD5	RGD	RGD:1563839
Canis familiaris	FASTKD5	VGNC	VGNC:40741
Others	FASTKD5	NCBI