WNT10A - Wnt family member 10A Gene

Also Known as OODD; SSPS; STHAG4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 80326

About WNT10A

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,874,116-218,893,928 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 8 phenotypes. Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal Cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

WNT10A Products (1)

mRNA	Protein	Name
NM_025216.3	NP_079492.2	protein Wnt-10a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables receptor ligand activity	IDA IDA: Inferred from direct assay	28733458	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28733458	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15040835	GOA
involved in epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	20163410	GOA
involved in hair follicle development	IMP IMP: Inferred from mutant phenotype	17847007	GOA
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	20163410	GOA
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	17847007	GOA
involved in sebaceous gland development	IMP IMP: Inferred from mutant phenotype	19559398	GOA
involved in skin development	IMP IMP: Inferred from mutant phenotype	17847007	GOA
involved in tongue development	IMP IMP: Inferred from mutant phenotype	17847007	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT10A Protein Structure

wnt

0
100
200
300
417 a.a.

Protein Preferred Names	Protein Names
protein Wnt-10a	wingless-type MMTV integration site family, member 10A

WNT10A 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81237	Wnt10a Antibody	WB, ELISA	Human, Mouse, Goat

関連疾患

Diseases	Alias
Odontoonychodermal Dysplasia	Odonto-Onycho-Dermal Dysplasia OODD Ectodermal Dysplasia 16, Hypo- Or Hyperhidrotic/Hair/Tooth/Nail Type Ectd16 Tricho-Odonto-Onycho-Dermal Dysplasia Dysplasia, Odontoonychodermal
Schopf-Schulz-Passarge Syndrome	SSPS Eccrine Tumors With Ectodermal Dysplasia Eccrine Tumors-Ectodermal Dysplasia Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis
Tooth Agenesis, Selective, 4	STHAG4 Tooth Agenesis, Selective, 4, With Or Without Ectodermal Dysplasia Lateral Incisors, Absence Of Lateral Incisors, Pegged Or Missing Succedaneous Teeth, Agenesis Of Absence Of Lateral Incisors Agenesis Of Succedaneous Teeth Pegged Or Missing Lateral Incisors Selective Tooth Agenesis 4
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Hypohidrotic Ectodermal Dysplasia Autosomal Recessive	Anhidrotic Ectodermal Dysplasia, Autosomal Recessive Autosomal Recessive Hypohidrotic Ectodermal Dysplasia Ar-Hed Autosomal Recessive Anhidrotic Ectodermal Dysplasia Autosomal Recessive Hypohidrotic Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Ectodermal Dysplasia 13, Hair/Tooth Type	ECTD13 Ectodermal Dysplasia 13
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked	Christ-Siemens-Touraine Syndrome XHED Ectodermal Dysplasia 1 Xlhed Ed1 Cst Syndrome Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked Ectd1 Ectodermal Dysplasia, Anhidrotic, X-Linked Eda Eda1 Hed1 Ectodermal Dysplasia 1, Anhidrotic X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia Hypohidrotic X-Linked Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, 1 Hypohidrotic Ectodermal Dysplasia, X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia X-Linked Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked Ectodermal Dysplasia Anhidrotic
Anodontia	Complete Absence Of Teeth Developmental Absence Of Tooth Total Anodontia Of Permanent And Deciduous Teeth Absence Of Permanent Teeth Anodontia Of Permanent Dentition Agomphiasis Agomphosis Anodontism Complete Developmental Absence Of Teeth Congenital Absence Of Teeth Congenital Complete Absence Of Teeth Congenital Edentia Absence Of Teeth Absent Teeth Congenital Partial Absence Of Teeth Partial Absence Of Teeth Partial Anodontia
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly	Fuhrmann Syndrome Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome Fuhrmann-Rieger-De Sousa Syndrome FUHRS Fibular Aplasia Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Hypotrichosis
Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	ECTD11B Hed Eda Ectodermal Dysplasia 11b Ectodermal Dysplasia, Hypohidrotic Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 11b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Ulna And Fibula, Absence Of, With Severe Limb Deficiency	Schinzel Phocomelia Syndrome Aarrs Limb/Pelvis-Hypoplasia/Aplasia Syndrome LPHAS Schinzel Type Phocomelia Absence Of Ulna And Fibula With Severe Limb Deficiency Al-Awadi/Raas-Rothschild Syndrome Al Awadi-Raas-Rothschild Syndrome Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome Aplasia/Hypoplasia Of Limbs And Pelvis Congenital Absence Of Ulna And Fibula Severe Limb Deficit Phocomelia, Schinzel Type Al-Awadi-Raas-Rothschild Syndrome Ulna And Fibula Absence Of With Severe Limb Deficiency Limb Pelvis Hypoplasia Aplasia Syndrome Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Hidrocystoma	Apocrine Cystadenoma Eccrine Hidrocystoma Eccrine Cystadenoma Eccrine Hidrocystoma Of Skin Apocrine Adenoma
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Focal Dermal Hypoplasia	Goltz Syndrome Goltz-Gorlin Syndrome FDH FODH Dhof Goltz Gorlin Syndrome Hypoplasia, Dermal, Focal
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Orofacial Cleft	Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS15828	WNT10A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	WNT10A	MGD	MGI:108071
Bos taurus	WNT10A	VGNC	VGNC:36954
Rattus norvegicus	WNT10A	RGD	RGD:1307015
Felis catus	WNT10A	VGNC	VGNC:107689
Macaca mulatta	WNT10A	VGNC	VGNC:104564
Canis familiaris	WNT10A	VGNC	VGNC:48420
Others	WNT10A	NCBI