ASCC2 - activating signal cointegrator 1 complex subunit 2 Gene
Also Known as p100; ASC1p100
生物種: Homo sapiens
遺伝子タイプ: protein coding
遺伝子ID: 84164
About ASCC2
Cytogenetic location: 22q12.2
Genomic coordinates (GRCh38): 22:29,788,611-29,838,274 (from NCBI)
This gene has 23 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in bone marrow (RPKM 13.0), testis (RPKM 12.7) and 25 other tissues.
Summary
Predicted to enable ubiquitin binding activity. Involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of activating signal cointegrator 1 complex. [provided by Alliance of Genome Resources, Apr 2022]
ASCC2 Products (33)
| mRNA | Protein | Name |
|---|---|---|
| NM_001242906.2 | NP_001229835.1 | activating signal cointegrator 1 complex subunit 2 isoform 2 |
| NM_001369920.1 | NP_001356849.1 | activating signal cointegrator 1 complex subunit 2 isoform 3 |
| NM_001369921.1 | NP_001356850.1 | activating signal cointegrator 1 complex subunit 2 isoform 1 |
| NM_001369922.1 | NP_001356851.1 | activating signal cointegrator 1 complex subunit 2 isoform 1 |
| NM_001369923.1 | NP_001356852.1 | activating signal cointegrator 1 complex subunit 2 isoform 1 |
| NM_001369924.1 | NP_001356853.1 | activating signal cointegrator 1 complex subunit 2 isoform 4 |
| NM_001369925.1 | NP_001356854.1 | activating signal cointegrator 1 complex subunit 2 isoform 5 |
| NM_001369926.1 | NP_001356855.1 | activating signal cointegrator 1 complex subunit 2 isoform 6 |
| NM_001369927.1 | NP_001356856.1 | activating signal cointegrator 1 complex subunit 2 isoform 6 |
| NM_001369928.1 | NP_001356857.1 | activating signal cointegrator 1 complex subunit 2 isoform 6 |
| NM_001369929.1 | NP_001356858.1 | activating signal cointegrator 1 complex subunit 2 isoform 7 |
| NM_001369930.1 | NP_001356859.1 | activating signal cointegrator 1 complex subunit 2 isoform 8 |
| NM_001369931.1 | NP_001356860.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369932.1 | NP_001356861.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369933.1 | NP_001356862.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369934.1 | NP_001356863.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369935.1 | NP_001356864.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369936.1 | NP_001356865.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369937.1 | NP_001356866.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369938.1 | NP_001356867.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369939.1 | NP_001356868.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369940.1 | NP_001356869.1 | activating signal cointegrator 1 complex subunit 2 isoform 9 |
| NM_001369941.1 | NP_001356870.1 | activating signal cointegrator 1 complex subunit 2 isoform 10 |
| NM_001369942.1 | NP_001356871.1 | activating signal cointegrator 1 complex subunit 2 isoform 11 |
| NM_001369943.1 | NP_001356872.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369944.1 | NP_001356873.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369945.1 | NP_001356874.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369946.1 | NP_001356875.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369947.1 | NP_001356876.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369948.1 | NP_001356877.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369949.1 | NP_001356878.1 | activating signal cointegrator 1 complex subunit 2 isoform 12 |
| NM_001369950.1 | NP_001356879.1 | activating signal cointegrator 1 complex subunit 2 isoform 13 |
| NM_032204.5 | NP_115580.2 | activating signal cointegrator 1 complex subunit 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables K63-linked polyubiquitin modification-dependent protein binding |
IDA
IDA: Inferred from direct assay
|
36302773 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28514442 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
12077347 | GOA |
| involved in rescue of stalled ribosome |
IDA
IDA: Inferred from direct assay
|
32579943 | GOA |
| involved in rescue of stalled ribosome |
IMP
IMP: Inferred from mutant phenotype
|
32099016 | GOA |
| involved in ribosome disassembly |
IDA
IDA: Inferred from direct assay
|
32579943 | GOA |
| involved in ribosome-associated ubiquitin-dependent protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
32099016 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of DNA repair complex |
IPI
IPI: Inferred from physical interaction
|
29997253 | GOA |
| part of activating signal cointegrator 1 complex |
IDA
IDA: Inferred from direct assay
|
12077347 | GOA |
| is active in cytosolic ribosome |
IDA
IDA: Inferred from direct assay
|
36302773 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
12077347 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
ASCC2 Protein Structure
CUE
CUE: CUE domain (469 - 508)
- 0
- 200
- 400
- 600
- 757 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
activating signal cointegrator 1 complex subunit 2 |
|
ASCC2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
ASCC2 | Q9H1I8 | ASCC3 | Homo sapiens | Q8N3C0 | 29997253 | |
|
Intra
|
ASCC2 | Q9H1I8 | ASCC3 | Homo sapiens | Q8N3C0 | 33961781 | |
|
Intra
|
ASCC2 | Q9H1I8 | ASCC3 | Homo sapiens | Q8N3C0 | 28514442 | |
|
Intra
|
ASCC2 | Q9H1I8 | ASCC3 | Homo sapiens | Q8N3C0 | 29997253 | |
|
Intra
|
ASCC2 | Q9H1I8 | ASCC3 | Homo sapiens | Q8N3C0 | 29997253 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
関連疾患
| Diseases | Alias | |
|---|---|---|
| Large Intestine Adenocarcinoma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| 製品番号 | 製品名 |
製品効果
|
純度 |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS01076 | ASCC2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | ASCC2 | VGNC | VGNC:59967 |
| Macaca mulatta | ASCC2 | VGNC | VGNC:69895 |
| Canis familiaris | ASCC2 | VGNC | VGNC:38171 |
| Bos taurus | ASCC2 | VGNC | VGNC:26204 |
| Rattus norvegicus | ASCC2 | RGD | RGD:1561422 |
| Mus musculus | ASCC2 | MGD | MGI:1922702 |
| Others | ASCC2 | NCBI |
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