ASCC3 - activating signal cointegrator 1 complex subunit 3 Gene

Also Known as RNAH; HELIC1; ASC1p200

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10973

About ASCC3

Cytogenetic location: 6q16.3 Genomic coordinates (GRCh38): 6:100,508,194-100,881,329 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in urinary bladder (RPKM 5.0), colon (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ASCC3 Products (3)

mRNA Protein Name
NM_001284271.2 NP_001271200.1 activating signal cointegrator 1 complex subunit 3 isoform c
NM_006828.4 NP_006819.2 activating signal cointegrator 1 complex subunit 3 isoform a
NM_022091.5 NP_071374.1 activating signal cointegrator 1 complex subunit 3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' DNA helicase activity IDA
IDA: Inferred from direct assay
22055184 GOA
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
32579943 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22055184 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA alkylation repair IDA
IDA: Inferred from direct assay
22055184 GOA
involved in DNA duplex unwinding IDA
IDA: Inferred from direct assay
22055184 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
32579943 GOA
involved in rescue of stalled ribosome IMP
IMP: Inferred from mutant phenotype
32099016 GOA
involved in ribosome disassembly IDA
IDA: Inferred from direct assay
32579943 GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
32099016 GOA
Cellular Component GO Annotation Evidence References Source
part of DNA repair complex IPI
IPI: Inferred from physical interaction
29997253 GOA
part of activating signal cointegrator 1 complex IDA
IDA: Inferred from direct assay
12077347 GOA
located in cytosol IDA
IDA: Inferred from direct assay
28757607 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
36302773 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12077347 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASCC3 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (479 - 653)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (779 - 856)

Sec63

Sec63: Sec63 Brl domain (978 - 1287)

DEAD

DEAD: DEAD/DEAH box helicase (1329 - 1494)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1616 - 1693)

Sec63

Sec63: Sec63 Brl domain (1812 - 2176)

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  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2202 a.a.
Protein Preferred Names Protein Names

activating signal cointegrator 1 complex subunit 3

  • ASC-1 complex subunit P200

ASCC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ASCC3 Q8N3C0 HCCS Homo sapiens P53701
Anti Tag CoIP
33961781
Intra
ASCC3 Q8N3C0 HCCS Homo sapiens P53701
Anti Tag CoIP
28514442
Intra
ASCC3 Q8N3C0 ASCC2 Homo sapiens Q9H1I8
Anti Bait CoIP
29997253
Cross: Cross-species interaction Intra: Intraspecies interaction

ASCC3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811280 HELIC1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Large Intestine Adenocarcinoma

  • Adenocarcinoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01077 ASCC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20859 Ascc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27374 Ascc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ASCC3 VGNC VGNC:69863
Felis catus ASCC3 VGNC VGNC:59968
Mus musculus ASCC3 MGD MGI:1925237
Canis familiaris ASCC3 VGNC VGNC:38172
Rattus norvegicus ASCC3 RGD RGD:1307995
Bos taurus ASCC3 VGNC VGNC:26205
Others ASCC3 NCBI