HTR3B - 5-hydroxytryptamine receptor 3B Gene

Also Known as 5-HT3B

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9177

About HTR3B

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,898,923-113,949,079 (from NCBI)

This gene has 3 transcripts (splice variants), 175 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

HTR3B Products (2)

mRNA	Protein	Name
NM_001363563.2	NP_001350492.1	5-hydroxytryptamine receptor 3B isoform 2
NM_006028.5	NP_006019.1	5-hydroxytryptamine receptor 3B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables serotonin-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	7565620	GOA
enables serotonin-gated monoatomic cation channel activity	IGI IGI: Inferred from genetic interaction	9950429	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	17392525	GOA
involved in serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	17392525	GOA
involved in serotonin-gated cation-selective signaling pathway	IDA IDA: Inferred from direct assay	9950429	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cell surface	IDA IDA: Inferred from direct assay	16571125	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21138434	GOA
part of serotonin-activated cation-selective channel complex	IGI IGI: Inferred from genetic interaction	9950429	GOA
part of serotonin-activated cation-selective channel complex	IPI IPI: Inferred from physical interaction	16116092	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR3B Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
441 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic

HTR3B 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83873	HTR3B Antibody (YA3570)	WB, ICC/IF, FC, ELISA	Human
HY-P83873A	HTR3B Antibody (YA3570)(PBS only)	WB, ICC/IF, FC, ELISA	Human

関連疾患

Diseases	Alias
Motion Sickness	Airsickness Carsickness Seasickness Travel Sickness Riders' Vertigo
Heroin Dependence
Myasthenic Syndrome, Congenital, 15	Congenital Myasthenic Syndrome 15 CMS15 Myasthenic Syndrome, Congenital, Without Tubular Aggregates Cmswta Myasthenic Syndrome, Congenital, 15, Without Tubular Aggregates Congenital Myasthenic Syndrome 15 Without Tubular Aggregates Myasthenic Syndrome, Congenital, Type 15, Without Tubular Aggregates
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 9 CMS9 Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Pigmented Paravenous Chorioretinal Atrophy	Pigmented Paravenous Retinochoroidal Atrophy PPCRA Pprca Atrophy, Chorioretinal, Pigmented Paravenous
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS06473	HTR3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	HTR3B	RGD	RGD:61820
Felis catus	HTR3B	VGNC	VGNC:67674
Canis familiaris	HTR3B	VGNC	VGNC:41830
Macaca mulatta	HTR3B	VGNC	VGNC:73543
Mus musculus	HTR3B	MGD	MGI:1861899
Bos taurus	HTR3B	VGNC	VGNC:29999
Others	HTR3B	NCBI