CRB3 - crumbs cell polarity complex component 3 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 92359

About CRB3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,463,777-6,467,221 (from NCBI)

This gene has 4 transcripts (splice variants), 105 orthologues and 3 paralogues. Broad expression in colon (RPKM 9.7), duodenum (RPKM 9.6) and 16 other tissues.

Summary

This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

CRB3 Products (3)

mRNA Protein Name
NM_139161.5 NP_631900.1 protein crumbs homolog 3 isoform a precursor
NM_174881.4 NP_777377.1 protein crumbs homolog 3 isoform b precursor
NM_174882.3 NP_777378.1 protein crumbs homolog 3 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
17332497 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17920587 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17332497 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
17332497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein crumbs homolog 3

  • crumbs 3, cell polarity complex component

CRB3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CRB3 Q9BUF7 EPB41L5 Homo sapiens Q9HCM4
Anti Tag CoIP
17920587
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Retinitis Pigmentosa 12

  • RP12

  • Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

  • Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

  • Rp With Or Without Pprpe

  • Retinitis Pigmentosa-12
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

  • Charcot-Marie-Tooth Disease Type 4f

  • CMT4F

  • Charcot-Marie-Tooth Disease, Type 4f

  • Charcot-Marie-Tooth Disease 4f

  • Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4f

  • Charcot-Marie-Tooth Neuropathy Type 4f

  • Dejerine-Sottas Disease
Pigmented Paravenous Chorioretinal Atrophy

  • Pigmented Paravenous Retinochoroidal Atrophy

  • PPCRA

  • Pprca

  • Atrophy, Chorioretinal, Pigmented Paravenous
Retinal Degeneration

  • Degeneration Of Retina
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03142 CRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus CRB3 MGD MGI:2670904
Rattus norvegicus CRB3 RGD RGD:1565035
Others CRB3 NCBI