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製品番号: HY-185450

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GlcB-IN-1

GlcB-IN-1 is an inhibitor of Mycobacterium malate synthase (GlcB) with an IC₅₀ of 1.05 μM. GlcB-IN-1 can be used for the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1346745-52-5
分子式: C₁₂H₉NO₄
分子量:231.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

GlcB-IN-1 構造式

CAS 番号: 1346745-52-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

GlcB-IN-1 is an inhibitor of Mycobacterium malate synthase (GlcB) with an IC₅₀ of 1.05 μM. GlcB-IN-1 can be used for the research of tuberculosis^[1].

体外実験

GlcB-IN-1 (compound 19) binds to malate synthase (GlcB) from Mycobacterium tuberculosis, and the resulting complex retains the closed active site lid and the "inward" conformation of the CoA-binding loop, forming a weak hydrogen bond with Met-631^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1346745-52-5
分子量 231.20
分子式 C₁₂H₉NO₄
SMILES

O=C(/C=C(C(O)=O)\O)C1=CNC2=CC=CC=C21
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Huang HL, et al. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J Biol Chem. 2016;291(53):27421-27432. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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