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Glembatumumab

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Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity.

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  • 純度: 99.69%
  • CAS 番号: 1020264-78-1
  • 分子量:145.56 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Glembatumumab
  • Experimental Validation Results for Glembatumumab
  • Experimental Validation Results for Glembatumumab
  • Glembatumumab Chemical Structure
    Glembatumumab 構造式
CAS 番号: 1020264-78-1
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Immobilized GPNMB/Osteoactivin Protein, Human (HEK293, His, HY-P70836) can bind Glembatumumab. The EC50 for this effect is 11.7 ng/mL.

  • 1/16

    Flow Cytometry analysis of L929 cells labelling GPNMB (red) with Glembatumumab (anti-GPNMB) (HY-P99205). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG2 kappa (HY-P99002). Black-Unlabelled control, cells without incubation with primary antibody.

  • Glembatumumab Chemical Structure
    1/16
  • Glembatumumab
  • Immobilized GPNMB/Osteoactivin Protein, Human (HEK293, His, HY-P70836) can bind Glembatumumab. The EC50 for this effect is 11.7 ng/mL.
  • Flow Cytometry analysis of L929 cells labelling GPNMB (red) with Glembatumumab (anti-GPNMB) (HY-P99205). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG2 kappa (HY-P99002). Black-Unlabelled control, cells without incubation with primary antibody.