Imidazole-5-propionic acid
Based on 1 publication(s) in Google Scholar
Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.99%
- CAS 番号: 1074-59-5
- 分子式: C6H8N2O2
- 分子量:140.14
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Imidazole-5-propionic acid
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Histological Imaging/Staining
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
Imidazole-5-propionic acid can be used in research on intestinal diseases[2].
Imidazole-5-propionic acid has emerged as a significant mediator linking gut microbiota dysbiosis to atherosclerosis and cardiovascular disease, or coronary artery disease (CAD)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1074-59-5
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性状 Solid
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分子量 140.14
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分子式 C6H8N2O2
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Color Off-white to light yellow
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SMILES
C(CC(=O)O)C1=CN=CN1
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別名
デアミノヒスチジン
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Med
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1. [Abstract]2025 Jan 16;31(1):14. PMID: 39819421
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (2-12 mM; 24-48 h) significantly decreased the viability of PC3 and DU145 cells in a dose-dependent manner.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (5-10 mM) significantly reduced the number of EdU-stained cells in the PC3 and DU145 cell lines.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (1-10 mM) reduced the migratory ability of PC3 and DU145 cells.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) significantly reduced tumor volume and weight in subcutaneous xenograft mice.
Imidazole-5-propionic acid purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 16;31(1):14. [Abstract]
Imidazole-5-propionic acid (IMP) (40 mg/mL; i.p.; twice a day) preserved tumor tissue structure, reduced Ki-67 expression, and increased PDZK1 expression in the tumor tissue of subcutaneous xenograft mice.
溶剤 & 溶解度
H2O : 100 mg/mL (713.57 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Deutsch - DE (393 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Wadud S, et al. In vitro catabolism of histidine by mixed rumen bacteria and protozoa. Curr Microbiol. 2001 Jan;42(1):12-7. [Content Brief]
[2]. van der Heiden C, et al. Increased urinary imidazolepropionic acid, N-acetylhistamine and other imidazole compounds in patients with intestinal disorders. Clin Chim Acta. 1972 Jun;39(1):201-14. [Content Brief]
[3]. Pinnelli VB, et al. The Role Played by Imidazole Propionic Acid in Modulating Gut-Heart Axis and the Development of Atherosclerosis: An Explorative Review. Cureus. 2025 Oct 11;17(10):e94362. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.1357 mL | 35.6786 mL | 71.3572 mL | 178.3930 mL |
| 5 mM | 1.4271 mL | 7.1357 mL | 14.2714 mL | 35.6786 mL | |
| 10 mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 17.8393 mL | |
| 15 mM | 0.4757 mL | 2.3786 mL | 4.7571 mL | 11.8929 mL | |
| 20 mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 8.9197 mL | |
| 25 mM | 0.2854 mL | 1.4271 mL | 2.8543 mL | 7.1357 mL | |
| 30 mM | 0.2379 mL | 1.1893 mL | 2.3786 mL | 5.9464 mL | |
| 40 mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 4.4598 mL | |
| 50 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5679 mL | |
| 60 mM | 0.1189 mL | 0.5946 mL | 1.1893 mL | 2.9732 mL | |
| 80 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2299 mL | |
| 100 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Imidazole-5-propionic acid 関連分類
HY-W045271 関連分類
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