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製品番号: HY-123225

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LCRF-0004

LCRF-0004 is a potent inhibitor of RON kinase, with the IC₅₀ value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC₅₀ value of 12 nM. LCRF-0004 plays an important role in cancer research.

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CAS 番号: 1229611-73-7
分子式: C₂₈H₁₈F₄N₆O₂S
分子量:578.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LCRF-0004 構造式

CAS 番号: 1229611-73-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.1 μM Compound: LCRF-0004	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 25953155]
A549	IC₅₀	0.4 μM Compound: 4	Inhibition of c-Met-mediated cell migration of human A549 cells by would healing Inhibition of c-Met-mediated cell migration of human A549 cells by would healing	[PMID: 20363625]
DU-145	IC₅₀	2 μM Compound: 4	Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells	[PMID: 20363625]
HCT-116	IC₅₀	0.08 μM Compound: 4	Antitumor activity against human HCT116 cells by MTT assay Antitumor activity against human HCT116 cells by MTT assay	[PMID: 20363625]
HCT-116	IC₅₀	0.08 μM Compound: LCRF-0004	Antiproliferative activity against human HCT116 cells by MTT assay Antiproliferative activity against human HCT116 cells by MTT assay	[PMID: 25953155]
HEK293	IC₅₀	0.05 μM Compound: 4	Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells Inhibition of TPR-tagged RON catalytic domain expressed in HEK293 cells	[PMID: 20363625]
HT-29	IC₅₀	30 nM Compound: LCRF-0004	Inhibition of RON phosphorylation in human HT29 cells Inhibition of RON phosphorylation in human HT29 cells	[PMID: 25953155]
MDA-MB-231	IC₅₀	0.1 μM Compound: LCRF-0004	Antiproliferative activity against human MDA-MB-231 cells by MTT assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay	[PMID: 25953155]
MKN-45	IC₅₀	0.5 μM Compound: 4	Inhibition of c-Met phosphorylation in human MKN45 cells Inhibition of c-Met phosphorylation in human MKN45 cells	[PMID: 20363625]
MKN-45	IC₅₀	6.87 μM Compound: LCRF-0004	Inhibition of phosphorylation of c-Met in human MKN45 cells Inhibition of phosphorylation of c-Met in human MKN45 cells	[PMID: 25953155]
MKN-45	IC₅₀	6.87 μM Compound: LCRF-0004	Inhibition of c-Met phosphorylation in human MKN45 cells Inhibition of c-Met phosphorylation in human MKN45 cells	[PMID: 26243370]
PC-3	IC₅₀	30 nM Compound: LCRF-0004	Inhibition of RON phosphorylation in human PC3 cells Inhibition of RON phosphorylation in human PC3 cells	[PMID: 25953155]

化学情報

CAS 番号 1229611-73-7
分子量 578.54
分子式 C₂₈H₁₈F₄N₆O₂S
SMILES

O=C(NC1=CC=C(C(F)=C1)OC2=C3C(C=C(S3)C4=CN(C=N4)C)=NC=C2)C5=C(N(N=C5)C6=CC=CC=C6)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Stéphane L Raeppel, et al. Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2527-31. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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