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United States

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製品番号: HY-P11893

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PSMA-HK9

PSMA-HK9 is a ligand targeting prostate-specific membrane antigen (PSMA) that binds to PSMA with high affinity, with a K_d value of 4.76 nM. PSMA-HK9 can be labeled with the diagnostic radionuclide 68Ga for imaging applications, and this labeled conjugate exhibits high tumor uptake and low normal tissue uptake in vivo. PSMA-HK9 can be labeled with the radionuclide 177Lu for targeted radionuclide studies, and this labeled conjugate possesses efficient cellular endocytosis and tumor inhibitory activity. PSMA-HK9 can be used in studies related to prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₅₉H₇₉N₁₁O₂₂
分子量:1294.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

PSMA-HK9 構造式

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価格（税別）

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

PSMA

4.76 nM (Kd)

体外実験

PSMA-HK9 binds to purified PSMA protein with high affinity, with a K_d value of 4.76 nM and a predicted binding energy of -9.7 kcal·mol⁻¹^[1].
PSMA-HK9 (120 min) competitively inhibits PSMA binding in RM1-PSMA cells, with a K_i value of 0.50 nM, exhibiting high target specificity and affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 1294.32
分子式 C₅₉H₇₉N₁₁O₂₂
配列

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
シーケンスの短縮

{Tetraxetan}-{d-Glu}-{d-Glu}-{Amb}-{b-hAla(2-naphthyl)}-{d-Orn}-{CO}-{d-Glu}
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Gao X, et al. Synthesis, Evaluation, and First-in-Human Study of a Novel PSMA Radioligand Bearing Beta-Amino Acid Linkage. Journal of medicinal chemistry. 2026 Mar 12;69(5):5610-5621.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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