Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium

  • J Nat Prod. 2024 Jul 26;87(7):1838-1843. doi: 10.1021/acs.jnatprod.4c00499.
Naoaki Kurisawa  1 ,  Ghulam Jeelani  2 ,  Tomoyoshi Nozaki  2 ,  Adnan Luthfi Agusta  2 ,  Kiyotake Suenaga  1 ,  Arihiro Iwasaki  3
Affiliations
  • 1. Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • 2. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • 3. Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
PMID: 39021085 DOI: 10.1021/acs.jnatprod.4c00499
Abstract

Here, we report wajeepeptin (1), a new cyclic depsipeptide isolated from a marine Moorena sp. cyanobacterium. The structure was elucidated by a combination of spectroscopic analyses, X-ray diffraction analysis, and degradation reactions. Wajeepeptin (1) showed moderate cytotoxicity (IC50 = 3.7 μM against HeLa cells) and potent antitrypanosomal activity (IC50 = 0.73 ± 0.14 μM against Trypanosoma brucei rhodesiense).