Effect of tibric acid on hepatic cholesterol synthesis in rats

  • Lipids. 1977 Aug;12(8):684-8. doi: 10.1007/BF02533766.
M N Cayen ,  J Dubuc ,  D Dvornik
PMID: 895418 DOI: 10.1007/BF02533766
Abstract

Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum Cholesterol and triglyceride levels were reduced, but total liver content of Cholesterol, Phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [14C] acetate and [3H] mevalonate into Cholesterol by liver homogenates.

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