R-6890
Based on 1 Customer Validation
R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.59%
- CAS 番号: 3222-88-6
- 分子式: C21H24ClN3O
- 分子量:369.89
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
R-6890 competitively binds to opiate receptors in rat brain P2 fraction with an IC50 of 4.6 nM in sodium-free buffer and 170 nM in sodium-containing buffer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 200 ± 5 g body weight)[1]
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Dosage:0.54 μmol/kg
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Administration:i.v.
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Result:Determined an intravenous ED50 of 0.54 μmol/kg for pronounced analgesia (reaction time >10 sec).
化学情報
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CAS 番号 3222-88-6
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性状 Solid
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分子量 369.89
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分子式 C21H24ClN3O
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Color White to off-white
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SMILES
O=C1NCN(C12CCN(C(C)C3=CC=C(C=C3)Cl)CC2)C4=CC=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Stahl KD, et al. Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs. Eur J Pharmacol. 1977;46(3):199-205. [Content Brief]
[2]. Marchei E, et al. Brorphine and Its Analogues: Pharmacology, Toxicology, and Biomonitoring. Ther Drug Monit. Published online February 2, 2026. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
R-6890 関連分類
HY-168366 関連分類
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