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製品番号: HY-182262

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Ro 20-0083

Ro 20-0083 is an orally active pancreatic lipase inhibitor. Ro 20-0083 inhibits hPancreatic lipase activity, reduces lipid absorption and de novo fatty acid synthesis. Ro 20-0083 decreases food intake in Zucker rats. Ro 20-0083 can be used in obesity-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 31478-25-8
分子式: C₃₃H₅₁N₂NaO₁₀
分子量:658.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ro 20-0083 構造式

CAS 番号: 31478-25-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Ro 20-0083 inhibits human pancreatic lipase in an in vitro assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Ro 20-0083 (240 mg/kg body weight; p.o. via diet admixture) produces a significant, dose-matched anorectic effect in both obese and lean male Zucker rats, reducing 24-hour food intake by 56-72%^[1].
Chronic administration of Ro 20-0083 (250 mg/kg) reduces body weight gain, as well as decreases body fat and triglyceride levels, in obese female Zucker rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 31478-25-8
分子量 658.76
分子式 C₃₃H₅₁N₂NaO₁₀
SMILES

CC[C@]1([C@]2([H])O[C@H]([C@@](CC2)(O[Na])CC)C)O[C@]([C@H](C1)C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC3=C(C(O)=C(C=C3[N+]([O-])=O)C)[N+]([O-])=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Drewnowski A, et al. Effects of inhibitors of carbohydrate absorption or lipid metabolism on meal patterns of Zucker rats. Pharmacol Biochem Behav. 1985;23(5):811-821. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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