SKF 83959
Based on 1 publication(s) in Google Scholar
SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.30%
- CAS 番号: 80751-85-5
- 分子式: C18H20ClNO2
- 分子量:317.81
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
GPCR/G Protein Compound Library
HY-L006
-
Neuronal Signaling Compound Library
HY-L013
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Antidepressant Compound Library
HY-L108
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Activators Library
HY-L159
-
Dopamine Receptor Compound Library
HY-L165
-
Allosteric Modulators (AMs) Compound Library
HY-L170
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
MedChemExpress（MCE）の使用を引用している文献 SKF 83959
MoreDopamine Receptor アイソフォーム固有の製品をすべて表示
MoreSigma Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
D1 Receptor 1.18 nM (Ki) |
Sigma 1 Receptor |
D5 Receptor 7.56 nM (Ki) |
D2 Receptor 920 nM (Ki) |
D3 Receptor 399 nM (Ki) |
SKF83959 (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 (0.1~10 μM; PC12 cell) changes the EC50 value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SKF83959 (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade[1].
SKF83959 has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male ICR male mice (8 weeks)[1]
-
Dosage:0.5 and 1 mg/kg
-
Administration:I.p.; 1 hour
-
Result:Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
-
Animal Model:Male ICR male mice (8 weeks)[1]
-
Dosage:1 mg/kg
-
Administration:I.p.; 30 minutes
-
Result:The memory enhancing effects were prevented by BDNF system blockade.
化学情報
-
CAS 番号 80751-85-5
-
性状 Solid
-
分子量 317.81
-
分子式 C18H20ClNO2
-
Color White to light yellow
-
SMILES
OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Nature
2023 Dec;624(7992):672-681. PMID: 37935376
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (314.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (282 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41(3):427-434. [Content Brief]
[2]. Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85(2):378-386. [Content Brief]
[3]. Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474(2-3):137-140. [Content Brief]
[4]. Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83(3):577-586. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1465 mL | 15.7327 mL | 31.4653 mL | 78.6634 mL |
| 5 mM | 0.6293 mL | 3.1465 mL | 6.2931 mL | 15.7327 mL | |
| 10 mM | 0.3147 mL | 1.5733 mL | 3.1465 mL | 7.8663 mL | |
| 15 mM | 0.2098 mL | 1.0488 mL | 2.0977 mL | 5.2442 mL | |
| 20 mM | 0.1573 mL | 0.7866 mL | 1.5733 mL | 3.9332 mL | |
| 25 mM | 0.1259 mL | 0.6293 mL | 1.2586 mL | 3.1465 mL | |
| 30 mM | 0.1049 mL | 0.5244 mL | 1.0488 mL | 2.6221 mL | |
| 40 mM | 0.0787 mL | 0.3933 mL | 0.7866 mL | 1.9666 mL | |
| 50 mM | 0.0629 mL | 0.3147 mL | 0.6293 mL | 1.5733 mL | |
| 60 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL | 1.3111 mL | |
| 80 mM | 0.0393 mL | 0.1967 mL | 0.3933 mL | 0.9833 mL | |
| 100 mM | 0.0315 mL | 0.1573 mL | 0.3147 mL | 0.7866 mL |
SKF 83959 関連分類
HY-130344 関連分類
Powered by Bioz