Atp2a2 - ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Gene

Also Known as Serca2; SercaII

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29693

Summary

Enables several functions, including ATP binding activity; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a2 Products (2)

mRNA	Protein	Name
NM_001110139.2	NP_001103609.1	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
NM_001110823.2	NP_001104293.1	sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12409282	RGD
enables P-type calcium transporter activity	IDA IDA: Inferred from direct assay	9851937	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	12409282	RGD
enables lutropin-choriogonadotropic hormone receptor binding	IPI IPI: Inferred from physical interaction	17588601	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9295312	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion import into sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	9851937	RGD
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	9851937	RGD
involved in calcium ion transport	IDA IDA: Inferred from direct assay	11595740	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	10748035	RGD
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IDA IDA: Inferred from direct assay	9851937	RGD
involved in regulation of cardiac muscle cell membrane potential	IDA IDA: Inferred from direct assay	9851937	RGD
involved in regulation of cardiac muscle contraction by calcium ion signaling	IDA IDA: Inferred from direct assay	9851937	RGD
involved in relaxation of cardiac muscle	IDA IDA: Inferred from direct assay	9851937	RGD
involved in relaxation of skeletal muscle	IEP IEP: Inferred from expression pattern	21993782	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	10748035	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	25712896	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	9295312	RGD
involved in sarcoplasmic reticulum calcium ion transport	IDA IDA: Inferred from direct assay	21300842	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical ectoplasmic specialization	IDA IDA: Inferred from direct assay	28486663	RGD
located in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20177054	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20177054	RGD
located in plasma membrane bounded cell projection	IDA IDA: Inferred from direct assay	28486663	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17901878	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	8447366	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ATPase, Ca++ transporting, slow twitch 2 SR Ca(2+)-ATPase 2 calcium pump 2 endoplasmic reticulum class 1/2 Ca(2+) ATPase sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2

Atp2a2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Atp2a2	P11507	Tlr9	Mus musculus	Q9EQU3	Anti Bait CoIP	24610369
Cross	Atp2a2	P11507	Tlr9	Mus musculus	Q9EQU3	Imaging	24610369

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131760	2'-NH2-ATP		/	Unkown
HY-131760A	2'-NH2-ATP tetrasodium		/	Unkown
HY-RS01192	ATP2A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01195	ATP2B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01199	ATP2C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17846	Atp2a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24314	Atp2a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2a2	NCBI	NCBI:488