Pseudouridine 5'-triphosphate
Based on 1 publication(s) in Google Scholar
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.
For research use only. We do not sell to patients.
- CAS No.: 1175-34-4
- Formula: C9H15N2O15P3
- Molecular Weight:484.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pseudouridine 5'-triphosphate
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Biological Activity
Pseudouridine 5'-triphosphate (1 mM) supports full transcription elongation of vaccinia virus early genes in vitro but dramatically inhibits VTF-dependent transcription termination, reducing termination efficiency to 25% in the bead-bound G21(TER29)A78 template system[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1175-34-4
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Molecular Weight 484.14
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Formula C9H15N2O15P3
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SMILES
O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CNC2=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Synonyms
Pseudo-UTP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. [Abstract]2023 May 23;42(6):112550. PMID: 37224018
Purity & Documentation
References
[1]. Shanmugasundaram M, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016;35(7):356-362. [Content Brief]
[2]. Mohamed MR, et al. Effect of UTP sugar and base modifications on vaccinia virus early gene transcription. Virology. 2006;349(2):359-370. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pseudouridine 5'-triphosphate Related Classifications
Cat. No.: HY-141567
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- Pseudouridine 5'-triphosphate
- 1175-34-4
- Pseudo-UTP
- DNA/RNA Synthesis
- vaccinia virus early gene transcription
- mRNA
- signal-dependent transcription termination
- transcription elongation
- vaccinia virus infection
- uracil base-modified UTP derivative
- modified ribonucleoside triphosphate
- innate immune responses
- mammalian cells
- Inhibitor
- inhibitor
- inhibit