country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184445

Copy Link Print Information

Antibacterial agent 355

Antibacterial agent 355 is a bacterial tRNA (m¹G37) methyltransferase (TrmD) inhibitor with an IC₅₀ of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC₅₀ of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₈H₃₀N₄O₃
분자량:470.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 355 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Antibacterial agent 355 (Compound 16) (100 μM; 2.5 h) inhibits growth of the hyper-permeable E. coli porin mutant strain by 99.3% at a concentration of 100 μM after 2.5 h of incubation at 37 °C^[1].
Antibacterial agent 355 (16 h) inhibits growth of the hyper-permeable E. coli porin mutant strain with an MIC of 167 μM after 16 h of incubation at 37 °C^[1].
Antibacterial agent 355 (100 μM; 0-8 h) selectively inhibits growth of hyper-permeable bacteria expressing E. coli TrmD, with rapid, near-complete inhibition by 2 h at 100 μM, while showing weaker, slower inhibition of bacteria expressing human Trm5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 470.56
화학식 C₂₈H₃₀N₄O₃
SMILES

O=C(N)C(C=C1)=CN=C1NCC(C)(C)C2=CC(CNC(/C=C/C(C3=CC=C(C)C=C3)=O)=O)=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Masuda, I., et al. (2026). Nicotinamide-Based Covalent Inhibitors of tRNA (m1G37) Methyltransferase (TrmD) to Increase Antibacterial Activity. ACS Medicinal Chemistry Letters.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기