BCATc Inhibitor 2
Based on 6 publication(s) in Google Scholar
BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm.
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- Purity: 99.28%
- CAS No.: 406191-34-2
- 화학식: C16H10ClF3N2O4S
- 분자량:418.77
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Neuroprotective Compound Library
HY-L070
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Neurodegenerative Disease-related Compound Library
HY-L086
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Targeted Diversity Library
HY-L099
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Amino Acid Metabolism Compound Library
HY-L189
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) BCATc Inhibitor 2
More- Nature. 2026 Apr;652(8112):1339-1348. [Abstract]
- Cell Metab. 2026 May 5;38(5):944-962.e14. [Abstract]
- Int J Biol Macromol. 2023 Jul 1;242(Pt 2):124870. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167220. [Abstract]
- Respir Physiol Neurobiol. 2022 Dec:306:103961. [Abstract]
- bioRxiv. 2024 July 05.
Biological Activity
IC50: 0.2 μM (rBCATc), 0.8 μM (hBCATc), 3.0 μM (rBCATm)[1].
BCATc Inhibitor 2 decreases calcium influx in neuronal cultures with an IC50=4.8±1.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Following a 30 mg/kg subcutaneous injection to Lewis rats, BCATc Inhibitor 2 reaches a peak plasma concentration (Cmax) of 8.28 μg/mL at 0.5 h (tmax). The mean plasma exposure (AUC) value is 19.9 μg h/mL, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 406191-34-2
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Appearance Solid
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분자량 418.77
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화학식 C16H10ClF3N2O4S
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Color White to off-white
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SMILES
ClC1=CC=C2C(C=C(O2)C(NNS(C3=C(C=CC=C3)C(F)(F)F)(=O)=O)=O)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8112):1339-1348. PMID: 41813904 -
Cell Metab
2026 May 5;38(5):944-962.e14. PMID: 41720105 -
Int J Biol Macromol
Branched-chain aminotransferase 1 promotes Schwann cell migration and proliferation to accelerate facial nerve regeneration through the Twist/FoxC1 and Sox2 pathways. [Abstract]2023 Jul 1;242(Pt 2):124870. PMID: 37196723 -
Biochim Biophys Acta Mol Basis Dis
Targeted inhibition of branched-chain amino acid metabolism drives apoptosis of glioblastoma by facilitating ubiquitin degradation of Mfn2 and oxidative stress. [Abstract]2024 Jun;1870(5):167220. PMID: 38718847 -
Respir Physiol Neurobiol
Branched-chain amino acid transaminase 1 inhibition attenuates childhood asthma in mice by effecting airway remodeling and autophagy. [Abstract]2022 Dec:306:103961. PMID: 35961527 -
용액&용해도
DMSO : 250 mg/mL (596.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3879 mL | 11.9397 mL | 23.8795 mL | 59.6986 mL |
| 5 mM | 0.4776 mL | 2.3879 mL | 4.7759 mL | 11.9397 mL | |
| 10 mM | 0.2388 mL | 1.1940 mL | 2.3879 mL | 5.9699 mL | |
| 15 mM | 0.1592 mL | 0.7960 mL | 1.5920 mL | 3.9799 mL | |
| 20 mM | 0.1194 mL | 0.5970 mL | 1.1940 mL | 2.9849 mL | |
| 25 mM | 0.0955 mL | 0.4776 mL | 0.9552 mL | 2.3879 mL | |
| 30 mM | 0.0796 mL | 0.3980 mL | 0.7960 mL | 1.9900 mL | |
| 40 mM | 0.0597 mL | 0.2985 mL | 0.5970 mL | 1.4925 mL | |
| 50 mM | 0.0478 mL | 0.2388 mL | 0.4776 mL | 1.1940 mL | |
| 60 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9950 mL | |
| 80 mM | 0.0298 mL | 0.1492 mL | 0.2985 mL | 0.7462 mL | |
| 100 mM | 0.0239 mL | 0.1194 mL | 0.2388 mL | 0.5970 mL |
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