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Cat. No.: HY-181518

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c-Kit-IN-15

c-Kit-IN-15 is a c-Kit inhibitor. c-Kit-IN-15 inhibits the c-Kit signaling pathway and suppresses cancer cell proliferation. c-Kit-IN-15 can be used in research related to hepatocellular carcinoma and breast cancer.

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화학식: C₃₉H₅₅NO₃
분자량:585.86

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

c-Kit-IN-15 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

c-Kit-IN-15 (Compound I9) (10 μM, 48 h) potently inhibits the proliferation of HepG-2 and MCF-7 cells, with IC₅₀ values of 8.94 μM and 9.64 μM, respectively^[1].
c-Kit-IN-15 (3-9 μM) downregulates the expression of c-Kit protein in MCF-7 cells in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human hepatocellular carcinoma HepG-2 cells, human breast cancer MCF-7 cells
Concentration:

10 μM; tested for IC₅₀ determination
Incubation Time:

48 h
Result:

Inhibited HepG-2 cell proliferation by 55.29% and MCF-7 cell proliferation by 50.44%.
Exhibited an IC₅₀ of 8.94 μmol/L in HepG-2 cells and 9.64 μmol/L in MCF-7 cells.

Chemical Information

분자량 585.86
화학식 C₃₉H₅₅NO₃
SMILES

O=C([C@]12CCC(C)(CC1C3=CCC4[C@]5(C=CC(C(C)(C5CC[C@]4([C@@]3(CC2)C)C)C)=O)C)C)OCCNC6=CC=CC(C)=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou X, et al. Design, synthesis, and antitumor activity study of novel oleanolic acid structural derivatives targeting c-Kit. Bioorg Med Chem Lett. Published online October 10, 2025. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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