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Cat. No.: HY-182696

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CGS 24891

CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC₅₀ value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B₄ (LTB₄) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC₅₀ of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.

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CAS No.: 134823-10-2
화학식: C₁₈H₁₇FN₂O₄
분자량:344.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGS 24891 Chemical Structure

CAS No.: 134823-10-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-LO

0.051 (gui μM (IC₅₀)

5-LO

0.11 (dogs μM (IC₅₀)

12-LOX

0.41 μM (IC₅₀)

All Lipoxygenase Isoforms :

In Vitro

CGS 24891 potently inhibits 5-lipoxygenase activity in guinea pig polymorphonuclear leukocytes (PMNs) with an IC₅₀ value of 51 nM^[1].
CGS 24891 inhibits the activity of 5-lipoxygenase in canine whole blood, with an IC₅₀ of 0.11 μM^[1].
CGS 24891 inhibits 12-lipoxygenase activity in platelets with an IC₅₀ of 0.41 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGS 24891 (1 mg/kg; p.o.) exerts a duration of action of 15 h in dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 134823-10-2
분자량 344.34
화학식 C₁₈H₁₇FN₂O₄
SMILES

O=C(N(CC1=CC2=C(OC1)C=CC(OC3=CC=C(C=C3)F)=C2)O)NC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Satoh Y, et al. Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. J Med Chem. 1993;36(23):3580-3594. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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CGS 24891

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CGS 24891 Related Classifications

HY-182696 Related Classifications