COX-2-IN-57
COX-2-IN-57 is an orally active COX-2 inhibitor with an IC50 value of 0.02 μM. COX-2-IN-57 reduces MyD88 expression and decreases serum levels of COX-2, PGE2, and COX-1 in Cisplatin (HY-17394)/radiation-induced neuropathy rat model. COX-2-IN-57 demonstrates superior antinociceptive efficacy in hot plate, cold allodynia, and Randall-Selitto tests, along with hepato-/renal protection. COX-2-IN-57 can be used for the study of inflammation.
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- 화학식: C34H23Cl2N3O4S
- 분자량:640.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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COX-2 0.02 μM (IC50) |
COX-1 |
COX-2-IN-57 (20 mg/kg, p.o., continuous administration for 5 days) significantly inhibits inflammation in cisplatin/γ-ray-induced inflammatory model of rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Carrageenan-induced paw edema and hyperalgesia model: 1% carrageenan solution (0.1 mL) was subcutaneously injected into the sub-plantar region of female Wistar rats to induce paw edema and hyperalgesia[1]
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Dosage:20 mg/kg
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Administration:p.o., once
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Result:Reduced paw edema increase percentage to 33.1% and elevated nociceptive threshold to 57 g.
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Animal Model:Cisplatin/γ-ray-induced inflammation and neuropathic pain model: Female Wistar rats (120-150 g) were intraperitoneally injected with cisplatin (2 mg/kg) to induce pain, and exposed to 4 Gy sublethal dose of γ-rays on the 4th day of the experiment to establish the model[1]
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Dosage:20 mg/kg
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Administration:p.o., continuous administration for 5 days
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Result:Decreased serum COX-2 level, serum PGE2 level and serum COX-1 level.
Increased latency time to hot stimulation, latency time to cold stimulation and paw withdrawal force under mechanical pressure.
Suppressed spinal MyD88 expression.
Showed apparently normal neurons in spinal grey matter with mild gliosis and slight vacuolation in spinal white matter.
Chemical Information
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분자량 640.54
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화학식 C34H23Cl2N3O4S
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SMILES
O=C(O)CC1=CC=CC=C1N(C2=C(Cl)C=CC=C2Cl)C(CSC(N3C4=CC=CC=C4)=NC5=C(C=C6C(C=CC=C6)=C5)C3=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-57 Related Classifications
HY-175637 Related Classifications
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