Curcumene
Based on 1 Customer Validation
Curcumene (α-Curcumene) is a monocyclic sesquiterpene found in the essential oil of rhizomes of Curcuma aromatica Salisb. Curcumene has antifungal and antibacterial activities. Curcumene can be used for the research of infection.
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- Purity: 99.47%
- CAS No.: 644-30-4
- 화학식: C15H22
- 분자량:202.34
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보관:
-80°C, protect from light
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Anti-Infection Compound Library
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Natural Product Library
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Antifungal Compound Library
HY-L048
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Antibacterial Compound Library
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Terpenoids Library
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Traditional Chinese Medicine Active Compound Library
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Natural Product and Natural Product-Like Compound Library
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Diarrhea-Related Traditional Chinese Medicine Active Compound Library
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Chinese Baijiu Compound Library
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Biological Activity
Curcumene shows inhibitory effect against Saccharomyces cerevisiae with estimated values of MIC and MFC 0.8 mg/mL[2].
Curcumene shows a synergistic antibacterial effect with antibiotics against Staphylococcus aureus, Escherichia coli, Enterobacter cloacae, Staphylococcus haemolyticus and Klebsiella pneumoniae[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 644-30-4
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Appearance Liquid (Density: 0.8537 g/cm3)
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분자량 202.34
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화학식 C15H22
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Color Colorless to light yellow
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SMILES
CC1=CC=C(C(C)CC/C=C(C)\C)C=C1
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Synonyms
α-Curcumene
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Structure Classification
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Initial Source
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선적
Shipping with dry ice.
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보관
-80°C, protect from light
용액&용해도
DMSO : 100 mg/mL (494.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (12.36 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (269 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9422 mL | 24.7109 mL | 49.4218 mL | 123.5544 mL |
| 5 mM | 0.9884 mL | 4.9422 mL | 9.8844 mL | 24.7109 mL | |
| 10 mM | 0.4942 mL | 2.4711 mL | 4.9422 mL | 12.3554 mL | |
| 15 mM | 0.3295 mL | 1.6474 mL | 3.2948 mL | 8.2370 mL | |
| 20 mM | 0.2471 mL | 1.2355 mL | 2.4711 mL | 6.1777 mL | |
| 25 mM | 0.1977 mL | 0.9884 mL | 1.9769 mL | 4.9422 mL | |
| 30 mM | 0.1647 mL | 0.8237 mL | 1.6474 mL | 4.1185 mL | |
| 40 mM | 0.1236 mL | 0.6178 mL | 1.2355 mL | 3.0889 mL | |
| 50 mM | 0.0988 mL | 0.4942 mL | 0.9884 mL | 2.4711 mL | |
| 60 mM | 0.0824 mL | 0.4118 mL | 0.8237 mL | 2.0592 mL | |
| 80 mM | 0.0618 mL | 0.3089 mL | 0.6178 mL | 1.5444 mL | |
| 100 mM | 0.0494 mL | 0.2471 mL | 0.4942 mL | 1.2355 mL |
Curcumene Related Classifications
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