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Cat. No.: HY-155074

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EGFR-IN-79

EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model.

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CAS No.: 3049072-04-7
화학식: C₂₃H₁₆ClN₃O₃
분자량:417.84

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

EGFR-IN-79 Chemical Structure

CAS No.: 3049072-04-7

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
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- Cellular Effect
Chemical Information
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Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	15.1 μM Compound: 21	Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37098306]
HT-1080	IC₅₀	13 μM Compound: 21	Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HT-1080 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37098306]
MCF7	IC₅₀	8.8 μM Compound: 21	Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37098306]
NHDF	IC₅₀	39.7 μM Compound: 21	Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human NHDF cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37098306]
SW-620	IC₅₀	10 μM Compound: 21	Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human SW620 cells assessed inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37098306]

Chemical Information

CAS No. 3049072-04-7
분자량 417.84
화학식 C₂₃H₁₆ClN₃O₃
SMILES

ClC1=CC=C(O)C(C2=CC(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NN2C4=CC=CC=C4)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leong SW, et al. Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells. Eur J Med Chem. 2023 Jun 5;254:115335. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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EGFR-IN-79

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EGFR-IN-79 Related Classifications

HY-155074 Related Classifications