FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L.
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- 화학식: C24H22N6O2
- 분자량:426.47
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 0.941 nM (FLT3) and 0.199 nM (FLT3/D835Y)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
866 nM
Compound: 22f
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Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
Growth inhibition of mouse BaF3 cells measured after 72 hrs by alamar blue cell viability assay
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[PMID: 37866334] |
Chemical Information
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분자량 426.47
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화학식 C24H22N6O2
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SMILES
O=C(N[C@H]1CC[C@H](N)C1)C2=CC=C(NN=C3C4=NC5=C(C=C(C6=COC=C6)C=C5)N4)C3=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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