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Cat. No.: HY-163466

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FXR agonist 7

FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC₅₀ of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity.

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CAS No.: 3036752-72-1
화학식: C₃₄H₃₆F₃N₃O₅
분자량:623.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

FXR agonist 7 Chemical Structure

CAS No.: 3036752-72-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC₅₀ of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity^[1].

Chemical Information

CAS No. 3036752-72-1
분자량 623.66
화학식 C₃₄H₃₆F₃N₃O₅
SMILES

O=C(C1=CN(C2=C1C=CC(N3CCC4(CC3)CC(C4)COCC5=C(ON=C5C6=CC=CC=C6OC(F)(F)F)C7CC7)=C2)CC)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yuan Li, et al. Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2024 Apr 11;67(7):5642-5661. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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