Cdx2 - caudal type homeobox 2 Gene

Also Known as Cdx-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12591

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in intestinal epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of somitogenesis. Acts upstream of or within several processes, including endosome to lysosome transport; establishment or maintenance of epithelial cell apical/basal polarity; and in utero embryonic development. Located in condensed nuclear chromosome. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; genitourinary system; and gut. Orthologous to human CDX2 (caudal type homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdx2 Products (1)

mRNA Protein Name
NM_007673.3 NP_031699.2 homeobox protein CDX-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16325584 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9512360 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16325584 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19796622 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
19853565 MGI
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
15788452 MGI
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
16396910 MGI
acts upstream of or within endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
20551175 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
20551175 MGI
involved in intestinal epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
22015720 MGI
acts upstream of or within labyrinthine layer development IGI
IGI: Inferred from genetic interaction
19853565 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16325584 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16325584 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
11959827 MGI
acts upstream of or within placenta development IGI
IGI: Inferred from genetic interaction
16396910 MGI
acts upstream of or within positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
16325584 MGI
acts upstream of or within positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
22190642 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9512360 MGI
involved in regulation of somitogenesis IMP
IMP: Inferred from mutant phenotype
22015720 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
16325584 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
20404091 MGI
acts upstream of trophectodermal cell differentiation IDA
IDA: Inferred from direct assay
16325584 MGI
acts upstream of or within trophectodermal cell differentiation IDA
IDA: Inferred from direct assay
16325584 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
15788452 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
15509711 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16325584 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19796622 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
16325584 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein CDX-2

  • caudal type homeo box 2

  • caudal-type homeobox protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-P1727 Super-TDU Antagonist 99.18% Unkown
HY-P1727A Super-TDU TFA Antagonist / Unkown
HY-RS02430 CDX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18606 Cdx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25092 Cdx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdx2 NCBI NCBI:1045