DMBT1 - deleted in malignant brain tumors 1 Gene

Also Known as SAG; GP340; SALSA; muclin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1755

About DMBT1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:122,560,754-122,643,736 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and 15 paralogues. Biased expression in duodenum (RPKM 482.0), small intestine (RPKM 157.2) and 1 other tissue.

Summary

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

DMBT1 Products (5)

mRNA	Protein	Name
NM_001320644.2	NP_001307573.1	deleted in malignant brain tumors 1 protein isoform d precursor
NM_001377530.1	NP_001364459.1	deleted in malignant brain tumors 1 protein isoform e precursor
NM_004406.3	NP_004397.2	deleted in malignant brain tumors 1 protein isoform a precursor
NM_007329.3	NP_015568.2	deleted in malignant brain tumors 1 protein isoform b precursor
NM_017579.3	NP_060049.2	deleted in malignant brain tumors 1 protein isoform c precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables heparan sulfate binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	19189310	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	19189310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10101009	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	19189310	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	11007786	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	19189310	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	11007786	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in induction of bacterial agglutination	IDA IDA: Inferred from direct assay	11007786	GOA
involved in induction of bacterial agglutination	IMP IMP: Inferred from mutant phenotype	11007786	GOA
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	19189310	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10485905	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11007786	GOA
located in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	10485905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMBT1 Protein Structure

SRCR

CUB

SRCR

CUB

Zona_pellucida

0
400
800
1200
1600
2000
2413 a.a.

Protein Preferred Names	Protein Names
deleted in malignant brain tumors 1 protein	glycoprotein 340

Recombinant DMBT1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P75710	DMBT1 Protein, Human (HEK293, His)	Q9UGM3/NP_004397.2 (T20-S220)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Anaplastic Astrocytoma	Grade Iii Astrocytoma Astrocytoma, Anaplastic Grade Iii Astrocytic Tumor
Glioma
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Enamel Caries	Primary Dental Caries Dental Caries Limited To Enamel Simple Dental Cavity
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03820	DMBT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19428	Dmbt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25919	Dmbt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DMBT1	VGNC	VGNC:39996
Mus musculus	DMBT1	MGD	MGI:106210
Rattus norvegicus	DMBT1	RGD	RGD:61984