TNRC6B - trinucleotide repeat containing adaptor 6B Gene

Also Known as GDSBA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23112

About TNRC6B

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,044,834-40,335,808 (from NCBI)

This gene has 9 transcripts (splice variants), 293 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 3.9), thyroid (RPKM 2.3) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2022]

TNRC6B Products (3)

mRNA Protein Name
NM_001024843.2 NP_001020014.1 trinucleotide repeat-containing gene 6B protein isoform 3
NM_001162501.2 NP_001155973.1 trinucleotide repeat-containing gene 6B protein isoform 1
NM_015088.3 NP_055903.2 trinucleotide repeat-containing gene 6B protein isoform 2

TNRC6B Protein Structure

Ago_hook

Ago_hook: Argonaute hook (940 - 1061)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (1664 - 1718)

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Protein Preferred Names Protein Names

trinucleotide repeat-containing gene 6B protein

  • trinucleotide repeat containing 6B

TNRC6B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNRC6B Q9UPQ9 CNOT1 Homo sapiens A5YKK6 21981923
Intra
TNRC6B Q9UPQ9 CNOT1 Homo sapiens A5YKK6 21981923
Intra
TNRC6B Q9UPQ9 PAN3 Homo sapiens Q58A45 21981923
Intra
TNRC6B Q9UPQ9 AGO2 Homo sapiens Q9UKV8 24043833
Intra
TNRC6B Q9UPQ9 AGO2 Homo sapiens Q9UKV8 24043833
Intra
TNRC6B Q9UPQ9 AGO2 Homo sapiens Q9UKV8 24043833
Intra
TNRC6B Q9UPQ9 AGO2 Homo sapiens Q9UKV8 24043833
Intra
TNRC6B Q9UPQ9 AGO2 Homo sapiens Q9UKV8
NMR
24043833
Intra
TNRC6B Q9UPQ9 PABPC1 Homo sapiens P11940 21063388
Intra
TNRC6B Q9UPQ9 PABPC1 Homo sapiens P11940 21981923
Cross
TNRC6B Q9UPQ9 pAbp Drosophila melanogaster P21187 21063388
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Global Developmental Delay With Speech And Behavioral Abnormalities
  • GDSBA

Non-Specific Syndromic Intellectual Disability
  • Complex Neurodevelopmental Disorder

Subserous Uterine Fibroid
  • Subserous Leiomyoma Of Uterus

Autism
  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic

Rectum Adenocarcinoma
  • Rectal Adenocarcinoma

  • Adenocarcinoma Of Rectum

Attention Deficit-Hyperactivity Disorder
  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity

Coffin-Siris Syndrome 1
  • Coffin-Siris Syndrome

  • Fifth Digit Syndrome

  • Css

  • CSS1

  • Mrd12

  • Mental Retardation, Autosomal Dominant 12

  • Hhid

  • Dwarfism-Onychodysplasia

  • Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

  • Autosomal Dominant Mental Retardation 12

  • Short Stature-Onychodysplasia.

  • Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

  • Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

  • Short Stature-Onychodysplasia

  • Coffin-Siris Syndrome, Type 1

  • Mental Retardation, Autosomal Dominant, Type 12

Strabismus
  • Strabismus, Susceptibility To

  • Strabismus, Susceptibility To, 1

  • Strabismus 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TNRC6B VGNC VGNC:36205
Macaca mulatta TNRC6B VGNC VGNC:79786
Felis catus TNRC6B VGNC VGNC:66434
Rattus norvegicus TNRC6B RGD RGD:621428
Canis familiaris TNRC6B VGNC VGNC:82302
Mus musculus TNRC6B MGD MGI:2443730
Others TNRC6B NCBI