Alox5ap - arachidonate 5-lipoxygenase activating protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29624

About Alox5ap

Primary_assembly 12: 5,748,944-5,772,986 reverse strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 201 orthologues, 3 paralogues and is associated with 23 phenotypes. Biased expression in Lung (RPKM 111.6), Spleen (RPKM 67.3) and 9 other tissues.

Summary

Enables enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; Lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in cytosol; endoplasmic reticulum; and nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Alox5ap Products (1)

mRNA Protein Name
NM_017260.2 NP_058956.1 arachidonate 5-lipoxygenase-activating protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to arachidonate 5-lipoxygenase activity IDA
IDA: Inferred from direct assay
2300173 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
19075240 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15084748 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15084748 RGD
Biological Process GO Annotation Evidence References Source
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
2300173 RGD
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
17517102 RGD
involved in lipoxygenase pathway IMP
IMP: Inferred from mutant phenotype
18945963 RGD
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
20519143 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
19075240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox5ap Protein Structure

MAPEG

MAPEG: pfam01124 (8 - 127)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

arachidonate 5-lipoxygenase-activating protein

  • 5-lipoxygenase-activating protein FLAP

  • FLAP

  • MK-886-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox5ap NCBI NCBI:241