Mthfr - methylenetetrahydrofolate reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362657

Summary

Enables NADP binding activity; flavin adenine dinucleotide binding activity; and methylenetetrahydrofolate reductase (NAD(P)H) activity. Involved in several processes, including homocysteine metabolic process; response to interleukin-1; and response to vitamin. Located in cytosol and synapse. Biomarker of hyperthyroidism; hypothyroidism; and liver benign neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic Cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]

Mthfr Products (5)

mRNA Protein Name
XM_006239414.4 XP_006239476.1 methylenetetrahydrofolate reductase isoform X3
XM_006239416.2 XP_006239478.1 methylenetetrahydrofolate reductase isoform X4
XM_006239417.2 XP_006239479.1 methylenetetrahydrofolate reductase isoform X4
XM_006239413.4 XP_006239475.1 methylenetetrahydrofolate reductase isoform X2
XM_342975.8 XP_342976.3 methylenetetrahydrofolate reductase isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
11730351 RGD
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
11730351 RGD
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IDA
IDA: Inferred from direct assay
11730351 RGD
Biological Process GO Annotation Evidence References Source
involved in S-adenosylmethionine metabolic process IEP
IEP: Inferred from expression pattern
1201245 RGD
involved in homocysteine metabolic process IEP
IEP: Inferred from expression pattern
18726220 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
737254 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
15313378 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15845641 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
18726220 RGD
involved in response to vitamin B2 IEP
IEP: Inferred from expression pattern
3676170 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
3088464 RGD
involved in tetrahydrofolate metabolic process IDA
IDA: Inferred from direct assay
11730351 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methylenetetrahydrofolate reductase

  • 5,10-methylenetetrahydrofolate reductase (NADPH)

  • methylenetetrahydrofolate reductase (NAD(P)H)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08778 MTHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20057 Mthfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26561 Mthfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mthfr NCBI NCBI:4524