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SCAPER - S-phase cyclin A associated protein in the ER Gene

Also Known as IDDRP; ZNF291; Zfp291; MSTP063

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 49855

About SCAPER

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,347,904-76,905,340 (from NCBI)

This gene has 23 transcripts (splice variants), 211 orthologues and is associated with 5 phenotypes. Broad expression in testis (RPKM 4.5), brain (RPKM 3.0) and 25 other tissues.

Summary

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

SCAPER Products (6)

mRNA	Protein	Name
NM_001145923.2	NP_001139395.1	S phase cyclin A-associated protein in the endoplasmic reticulum isoform b
NM_001353009.2	NP_001339938.1	S phase cyclin A-associated protein in the endoplasmic reticulum isoform c
NM_001353010.2	NP_001339939.1	S phase cyclin A-associated protein in the endoplasmic reticulum isoform d
NM_001353011.2	NP_001339940.1	S phase cyclin A-associated protein in the endoplasmic reticulum isoform e
NM_001353012.2	NP_001339941.1	S phase cyclin A-associated protein in the endoplasmic reticulum isoform d
NM_020843.4	NP_065894.2	S phase cyclin A-associated protein in the endoplasmic reticulum isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17698606	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	28794130	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAPER Protein Structure

zf-met

0
300
600
900
1200
1400 a.a.

Protein Preferred Names	Protein Names
S phase cyclin A-associated protein in the endoplasmic reticulum	zinc finger protein 291

SCAPER Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCAPER	Q9BY12	CDK2	Homo sapiens	P24941	Anti Tag CoIP	17698606
Intra	SCAPER	Q9BY12	CDK2	Homo sapiens	P24941	Anti Bait CoIP	17698606

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder And Retinitis Pigmentosa	IDDRP
Speech Disorder	Speech Disorders
Brachydactyly
Syndromic Rod-Cone Dystrophy	Syndromic Retinitis Pigmentosa
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Combined Oxidative Phosphorylation Deficiency 16	COXPD16 Infantile Hypertrophic Cardiomyopathy Due To Mrpl44 Deficiency Combined Oxidative Phosphorylation Defect Type 16 Combined Oxidative Phosphorylation Deficiency, Type 16
Cardiomyopathy, Dilated, 1l	Dilated Cardiomyopathy 1l CMD1L Cardiomyopathy, Dilated 1l Cardiomyopathy, Dilated, Type 1l
Blount'S Disease	Blount Disease Tibia Vara Osteochondrosis Deformans Tibiae Osteochondrosis Deformans Tibiae, Familial Infantile Type Familial Infantile Type Osteochondrosis Deformans Tibiae Blount-Barber Syndrome Erlacher-Blount Syndrome Infantile Tibia Vara Tibia Vara Blount Blount Disease, Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS12485	SCAPER Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCAPER	VGNC	VGNC:34321
Felis catus	SCAPER	VGNC	VGNC:64899
Canis familiaris	SCAPER	VGNC	VGNC:45895
Rattus norvegicus	SCAPER	RGD	RGD:621585
Macaca mulatta	SCAPER	VGNC	VGNC:77006
Mus musculus	SCAPER	MGD	MGI:1925976
Others	SCAPER	NCBI