LAPTM4B - lysosomal protein transmembrane 4 beta Gene

Also Known as LC27; LAPTM4beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55353

About LAPTM4B

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,775,788-97,853,013 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues.

Summary

Enables ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAPTM4B Products (1)

mRNA Protein Name
NM_018407.6 NP_060877.4 lysosomal-associated transmembrane protein 4B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide binding IDA
IDA: Inferred from direct assay
26280656 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
25588945 GOA
enables phosphatidylinositol bisphosphate binding IDA
IDA: Inferred from direct assay
25588945 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20711237 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25588945 GOA
Biological Process GO Annotation Evidence References Source
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
21224396 GOA
involved in endosome transport via multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
25588945 GOA
involved in negative regulation of lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25588945 GOA
involved in negative regulation of transforming growth factor beta1 production IDA
IDA: Inferred from direct assay
26126825 GOA
involved in regulation of lysosomal membrane permeability IMP
IMP: Inferred from mutant phenotype
26280656 GOA
involved in regulation of lysosome organization IMP
IMP: Inferred from mutant phenotype
26280656 GOA
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
22096579 GOA
located in early endosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in endosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
21224396 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21224396 GOA
located in lysosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
25588945 GOA
located in multivesicular body, internal vesicle IDA
IDA: Inferred from direct assay
26280656 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22096579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM4B Protein Structure

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (155 - 317)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

lysosomal-associated transmembrane protein 4B

  • lysosomal associated protein transmembrane 4 beta

LAPTM4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAPTM4B Q86VI4 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 ISLR2 Homo sapiens Q6UXK2
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 ISLR2 Homo sapiens Q6UXK2
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 EXOC4 Homo sapiens Q96A65
Anti Bait CoIP
25594178
Intra
LAPTM4B Q86VI4 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
25594178
Intra
LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gallbladder Cancer

  • Gallbladder Carcinoma

  • Gallbladder Neoplasm

  • Malignant Neoplasm Of Gallbladder

  • Malignant Tumour Of Gallbladder

  • Gallbladder Ca

  • Localized Malignant Gallbladder Neoplasm

  • Malignant Tumor Of The Gallbladder

  • Tumor Of The Gallbladder

  • Cancer Of The Gallbladder

  • Carcinoma Gallbladder

  • Carcinoma Of Gallbladder

  • Gallbladder Neoplasms

  • Malignant Neoplasm Of Gallbladder Localized

  • Cancer Of Gallbladder

  • Primary Malignant Neoplasm Of Gallbladder
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS07522 LAPTM4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22008 Laptm4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28526 Laptm4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LAPTM4B VGNC VGNC:81664
Canis familiaris LAPTM4B VGNC VGNC:54319
Mus musculus LAPTM4B MGD MGI:1890494
Macaca mulatta LAPTM4B VGNC VGNC:84010
Rattus norvegicus LAPTM4B RGD RGD:1311853
Others LAPTM4B NCBI