C4BPB - complement component 4 binding protein beta Gene

Also Known as C4BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 725

About C4BPB

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,088,860-207,099,993 (from NCBI)

This gene has 8 transcripts (splice variants), 76 orthologues and 39 paralogues. Biased expression in liver (RPKM 52.4) and ovary (RPKM 16.6).

Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 Amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each Other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

C4BPB Products (5)

mRNA Protein Name
NM_000716.3 NP_000707.1 C4b-binding protein beta chain isoform 1 precursor
NM_001017364.1 NP_001017364.1 C4b-binding protein beta chain isoform 2 precursor
NM_001017365.3 NP_001017365.1 C4b-binding protein beta chain isoform 1 precursor
NM_001017366.3 NP_001017366.1 C4b-binding protein beta chain isoform 2 precursor
NM_001017367.1 NP_001017367.1 C4b-binding protein beta chain isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14607961 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of complement activation, classical pathway IDA
IDA: Inferred from direct assay
22333221 GOA
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
22333221 GOA
involved in regulation of opsonization IDA
IDA: Inferred from direct assay
22333221 GOA
involved in response to symbiotic bacterium IDA
IDA: Inferred from direct assay
22333221 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
14607961 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C4BPB Protein Structure

Sushi

Sushi: Sushi repeat (SCR repeat) (23 - 76)

Sushi

Sushi: Sushi repeat (SCR repeat) (81 - 134)

Sushi

Sushi: Sushi repeat (SCR repeat) (139 - 191)

  • 0
  • 100
  • 200
  • 252 a.a.
Protein Preferred Names Protein Names

C4b-binding protein beta chain

C4BPB Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P82128 C4 Binding Protein Antibody (YA1873) WB, IHC-P, ICC/IF, IP Human, Rat

Related Diseases

Diseases Alias
Patellar Tendinitis

  • Patellar Tendonitis
Hemolytic Uremic Syndrome, Atypical 1

  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS01748 C4BPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris C4BPB VGNC VGNC:38594
Macaca mulatta C4BPB VGNC VGNC:99859
Bos taurus C4BPB VGNC VGNC:26640
Felis catus C4BPB VGNC VGNC:107846
Rattus norvegicus C4BPB RGD RGD:2236
Others C4BPB NCBI