Idebenone-SS-20
Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a Idebenone (HY-N0303) derivative conjugated to the mitochondria-targeting peptide SS-20. Idebenone-SS-20 shows neuroprotective and anti-inflammatory effects. Idebenone-SS-20 can preserve mitochondrial membrane potential, enhance ATP production, reduce ROS accumulation, maintain mitochondrial morphology and elevate NAD+/NADH ratio. Idebenone-SS-20 confers robust neuroprotection in a murine model of transient middle cerebral artery occlusion. Idebenone-SS-20 can be used for the research of cerebral.
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- 화학식: C55H81N9O11S2
- 분자량:1108.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Idebenone-SS-20 (Compound W1a) (0.625-5 μM; 24 h) protects HT22 hippocampal neuronal cells from glutamate-induced injury with an EC50 of 0.713 μM and has an IC50 of 68.4 μM for cytotoxicity[1].
Idebenone-SS-20 (5 μM; 12 h) restores ATP production, protects mitochondrial morphology, reduces superoxide production, and restores membrane potential in glutamate-injured HT22 hippocampal neuronal cells more effectively than Idebenone (HY-N0303)[1].
Idebenone-SS-20 (10 μM; 24 h) inhibits LPS (HY-D1056)-induced inflammation in BV2 microglial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV2 microglial cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly inhibited LPS-induced upregulation of Il6, Tnf, and Il1b mRNA levels (with greater efficacy than idebenone) and preserved mitochondrial length and morphology.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (male, 8-10 weeks, 22 ± 2 g, transient middle cerebral artery occlusion)[1]
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Dosage:20 mg/kg
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Administration:I.p.; twice (immediately after surgery and at reperfusion onset)
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Result:Significantly reduced cerebral infarct volume and suppressed neuronal death.
Increased 7-day survival rate and improved neurological recovery as measured by higher Garcia scores and longer rotarod latencies.
Restored mitochondrial gene expression (mitochondrial respiratory chain complex I assembly, electron transport chain activity, proton-driven ATP synthesis pathways).
Elevated NAD+/NADH ratio and ATP levels in brain tissue and reduced ROS accumulation.
Attenuated mitochondrial structural damage (swelling, cristae disintegration) and suppressed pro-inflammatory pathways (IL-17, NF-κB, TNF signaling) and glial (microglial, astrocytic) activation.
Chemical Information
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분자량 1108.42
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화학식 C55H81N9O11S2
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SMILES
COC1=C(OC)C(C(CCCCCCCCCCOC(CCSSCCC(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=C(C)C1=O)=O
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Synonyms
Idebenone-2S-FrFK-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Idebenone-SS-20 Related Classifications
HY-181124 Related Classifications
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