Nizatidine-d3
Based on 1 Customer Validation
Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models.
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- Purity: 98.80%
- CAS No.: 1246833-99-7
- 화학식: C12H18D3N5O2S2
- 분자량:334.48
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H2 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246833-99-7
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Unlabeled Cas 76963-41-2
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Appearance Solid
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분자량 334.48
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화학식 C12H18D3N5O2S2
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Color White to off-white
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SMILES
CN(C)CC1=NC(CSCCN/C(NC([2H])([2H])[2H])=C/[N+]([O-])=O)=CS1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : ≥ 50 mg/mL (149.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (59.79 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. T M Lin, et al. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. J Pharmacol Exp Ther. 1986 Nov;239(2):406-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.9897 mL | 14.9486 mL | 29.8972 mL | 74.7429 mL |
| 5 mM | 0.5979 mL | 2.9897 mL | 5.9794 mL | 14.9486 mL | |
| 10 mM | 0.2990 mL | 1.4949 mL | 2.9897 mL | 7.4743 mL | |
| 15 mM | 0.1993 mL | 0.9966 mL | 1.9931 mL | 4.9829 mL | |
| 20 mM | 0.1495 mL | 0.7474 mL | 1.4949 mL | 3.7371 mL | |
| 25 mM | 0.1196 mL | 0.5979 mL | 1.1959 mL | 2.9897 mL | |
| 30 mM | 0.0997 mL | 0.4983 mL | 0.9966 mL | 2.4914 mL | |
| 40 mM | 0.0747 mL | 0.3737 mL | 0.7474 mL | 1.8686 mL | |
| 50 mM | 0.0598 mL | 0.2990 mL | 0.5979 mL | 1.4949 mL | |
| DMSO | 60 mM | 0.0498 mL | 0.2491 mL | 0.4983 mL | 1.2457 mL |
| 80 mM | 0.0374 mL | 0.1869 mL | 0.3737 mL | 0.9343 mL | |
| 100 mM | 0.0299 mL | 0.1495 mL | 0.2990 mL | 0.7474 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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