pep2-SVKI
pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1). pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). pep2-SVKI can be used to study neurological diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 328944-75-8
- 화학식: C60H93N13O18
- 분자량:1284.46
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All iGluR Isoforms
More
Biological Activity
pep2-SVKI (1 mM) reduces (Miniature Excitatory Postsynaptic Current) mEPSC amplitude at both −60 mV and +40 mV in the synaptic membrane of stellate cells[1].
pep2-SVKI (100 μM) causes an increase in AMPAR-mediated (Excitatory Postsynaptic Current) EPSCs in hippocampal CA1 Neurons[2].
pep2-SVKI (100 μM) prevents the expression of LTD in a (Protein Kinase C) PKC-Dependent Manner in hippocampal CA1 Neurons[2].
pep2-SVKI increases tritium release induced by exposure to 100 μM AMPA in hippocampal synaptosomes prelabeled with (radiolabeled norepinephrine) [3H]NA and potentiates the AMPA-evoked release of [3H]NA in rat hippocampal synaptosomes[3].
pep2-SVKI causes increase in the number of AMPARs exposed on the membrane in rat hippocampal synaptosomes[3].
pep2-SVKI abolishes the sensitivity to Cyclothiazide (HY-101165) of the AMPA receptors controlling [3H]NA release[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 328944-75-8
-
분자량 1284.46
-
화학식 C60H93N13O18
-
Sequence
Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Ile
-
Sequence Shortening
YNVYGIESVKI
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
[2]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86. [Content Brief]
[3]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
pep2-SVKI Related Classifications
HY-P1056 Related Classifications
Powered by Bioz