328944-75-8
Chemical Structure
pep2-SVKI
- CAS No.: 328944-75-8
- Formula:C60H93N13O18
- Molecular Weight:1284.46
IUPAC Name: (2S,5S,8S,11S,14S)-14-((2S,8S,11S,14S,17S)-17-amino-14-(2-amino-2-oxoethyl)-2-((S)-sec-butyl)-8-(4-hydroxybenzyl)-18-(4-hydroxyphenyl)-11-isopropyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecanamido)-5-(4-aminobutyl)-2-((S)-sec-butyl)-11-(hydroxymethyl)-8-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid
InChIKey: YWTNLHXVGSIPEM-YDSVATBTSA-N
SMILES: O=C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N
Biological Activity: pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1). pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). pep2-SVKI can be used to study neurological diseases[1][2][3][4].
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pep2-SVKI | pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1). pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). pep2-SVKI can be used to study neurological diseases. | |||||||||||||||||||||
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- [1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
- [2]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86. [Content Brief]
- [3]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
Keywords
