5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

  • Bioorg Med Chem Lett. 2003 May 5;13(9):1543-7. doi: 10.1016/s0960-894x(03)00180-x.
Patrick Angibaud  1 ,  Xavier Bourdrez ,  Ann Devine ,  David W End ,  Eddy Freyne ,  Yannick Ligny ,  Philippe Muller ,  Geert Mannens ,  Isabelle Pilatte ,  Virginie Poncelet ,  Stacy Skrzat ,  Gerda Smets ,  Jacky Van Dun ,  Pieter Van Remoortere ,  Marc Venet ,  Walter Wouters
Affiliations
  • 1. Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research & Development, Campus de Maigremont BP615, 27106 Val de Reuil, France. [email protected]
PMID: 12699751 DOI: 10.1016/s0960-894x(03)00180-x
Abstract

The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.