Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor

  • J Nat Prod. 2009 Apr;72(4):666-70. doi: 10.1021/np800777f.
Leith J Fremlin  1 ,  Andrew M Piggott ,  Ernest Lacey ,  Robert J Capon
Affiliations
  • 1. Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.
PMID: 19245260 DOI: 10.1021/np800777f
Abstract

An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known Fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (-)-cyclopenol, and viridicatol, along with a new alkaloid, cottoquinazoline A (1), and two new cyclopentapeptides, cotteslosins A (2) and B (3). Structures for 1-3 and the known compounds were determined by spectroscopic analysis. The absolute configurations of 1-3 were addressed by chemical degradation and application of the C(3) Marfey's method. The use of "cellophane raft" high-nutrient media as a device for up-regulating secondary metabolite diversity in marine-derived fungi is discussed. The Antibacterial properties displayed by A. versicolor (MST-MF495) were attributed to the Phenols violaceol I, violaceol II, and diorcinol, while cotteslosins 2 and 3 were identified as weak cytotoxic agents.

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