8-nitro-cGMP--a new player in antibacterial autophagy

  • Mol Cell. 2013 Dec 26;52(6):767-8. doi: 10.1016/j.molcel.2013.12.006.
Moran Rawet-Slobodkin  1 ,  Zvulun Elazar  2
Affiliations
  • 1. Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
  • 2. Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: [email protected].
PMID: 24373745 DOI: 10.1016/j.molcel.2013.12.006
Abstract

In this issue of Molecular Cell, Ito et al. (2013) identify 8-nitro-cGMP as a new Autophagy Inducer mediating the clearance of invading bacteria in a mechanism that depends on protein S-guanylation and Lys63-linked ubiquitination. This study reveals an additional link between the innate immune response and Autophagy.

Products