The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1387-90. doi: 10.1016/s0960-894x(98)00235-2.
Y Fukuda  1 ,  H Furuta ,  Y Kusama ,  H Ebisu ,  Y Oomori ,  S Terashima
Affiliations
  • 1. Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi, Japan.
PMID: 9871771 DOI: 10.1016/s0960-894x(98)00235-2
Abstract

The novel 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, 7f in which two MCTFCPI moieties are connected with a 5,5'-bis(2-carbonyl-1H-indole) group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (2).