R-6890
Based on 1 Customer Validation
R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats.
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- Purity: 99.59%
- CAS No.: 3222-88-6
- 화학식: C21H24ClN3O
- 분자량:369.89
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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All Opioid Receptor Isoforms
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Biological Activity
R-6890 competitively binds to opiate receptors in rat brain P2 fraction with an IC50 of 4.6 nM in sodium-free buffer and 170 nM in sodium-containing buffer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 200 ± 5 g body weight)[1]
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Dosage:0.54 μmol/kg
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Administration:i.v.
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Result:Determined an intravenous ED50 of 0.54 μmol/kg for pronounced analgesia (reaction time >10 sec).
Chemical Information
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CAS No. 3222-88-6
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Appearance Solid
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분자량 369.89
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화학식 C21H24ClN3O
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Color White to off-white
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SMILES
O=C1NCN(C12CCN(C(C)C3=CC=C(C=C3)Cl)CC2)C4=CC=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Stahl KD, et al. Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs. Eur J Pharmacol. 1977;46(3):199-205. [Content Brief]
[2]. Marchei E, et al. Brorphine and Its Analogues: Pharmacology, Toxicology, and Biomonitoring. Ther Drug Monit. Published online February 2, 2026. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R-6890 Related Classifications
HY-168366 Related Classifications
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