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Cat. No.: HY-186042

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TPα/β antagonist-1

TPα/β antagonist-1 is a TXA2 receptor α (TPα) and TPβ antagonist with IC₅₀s of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits U-46619 (HY-108566)-induced intracellular calcium mobilization, and imhibits platelet aggregation. TPα/β antagonist-1 can be used for the research of cardiovascular disease.

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CAS No.: 899789-84-5
화학식: C₂₀H₂₃N₃O₆S
분자량:433.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

TPα/β antagonist-1 Chemical Structure

CAS No.: 899789-84-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

TPα

1.52 nM (IC₅₀)

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	0.79 nM Compound: 7d	Displacement of [3H]SQ-29548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uM Displacement of [3H]SQ-29548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uM	[PMID: 16759113]

In Vitro

TPα/β antagonist-1 (compound 7d) binds to both TPα and TPβ receptors with preferential affinity for TPβ (IC₅₀ TPα = 1.52 nM, IC₅₀ TPβ = 0.79 nM)^[1].
TPα/β antagonist-1 antagonizes U-46619 (HY-108566)-mediated calcium mobilization with greater potency for TPβ (IC₅₀ TPα = 600.71 nM, IC₅₀ TPβ = 70.15 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 899789-84-5
분자량 433.48
화학식 C₂₀H₂₃N₃O₆S
SMILES

O=C(NC1CCCCC1)NS(=O)(C2=CC([N+]([O-])=O)=CC=C2OC3=CC=C(C=C3)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hanson J, et al. Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem. 2006;49(12):3701-3709. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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TPα/β antagonist-1

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TPα/β antagonist-1 Related Classifications

HY-186042 Related Classifications