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Art. -Nr.: HY-126758

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Ludartin

Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury.

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CAS. Nr.: 36149-87-8
Formel: C₁₅H₁₈O₃
Molecular Weight:246.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Ludartin Chemical Structure

CAS. Nr.: 36149-87-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	19 μM Compound: Ludartin	Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31784199]
A549	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
A549	IC₅₀	7.4 μM Compound: 1	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
A549	IC₅₀	7.4 μM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
B16-F10	IC₅₀	6.6 μM Compound: Ludartin	Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31784199]
BHY	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
COLO 205	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
HCT-116	IC₅₀	6.9 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
HCT-116	IC₅₀	6.9 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
MCF7	IC₅₀	0.5 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
MCF7	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
MIA PaCa-2	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
PC-3	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
PC-3	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
T98G	IC₅₀	6.3 μM Compound: 1	Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
THP-1	IC₅₀	3.1 μM Compound: 1	Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
THP-1	IC₅₀	3.1 μM Compound: 1	Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]

Chemical Information

CAS. Nr. 36149-87-8
Molecular Weight 246.30
Formel C₁₅H₁₈O₃
SMILES

C[C@]12[C@]3([H])[C@]4([H])[C@](CCC(C)=C3C[C@@]1([H])O2)([H])C(C(O4)=O)=C
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu Wei, et al., Ludartin exhibits therapeutic effect on spinal cord injury through inhibition of apoptosis and inflammation[J]. 2019.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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Ludartin

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Ludartin Related Classifications

HY-126758 Related Classifications