2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Glutathione Peroxidase
  4. Ludartin

Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury.

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Ludartin

Ludartin Chemical Structure

CAS No. : 36149-87-8

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Ludartin Related Antibodies

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Description

Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury[1].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
19 μM
Compound: Ludartin
Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31784199]
A549 IC50
25.18 μM
Compound: Ludartin
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31784199]
A549 IC50
7.4 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
[PMID: 23886685]
A549 IC50
7.4 μM
Compound: 1
Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
B16-F10 IC50
6.6 μM
Compound: Ludartin
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 31784199]
BHY IC50
25.18 μM
Compound: Ludartin
Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31784199]
COLO 205 IC50
25.18 μM
Compound: Ludartin
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31784199]
HCT-116 IC50
6.9 μM
Compound: 1
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
[PMID: 23886685]
HCT-116 IC50
6.9 μM
Compound: 1
Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
MCF7 IC50
0.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
MCF7 IC50
25.18 μM
Compound: Ludartin
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31784199]
MIA PaCa-2 IC50
25.18 μM
Compound: Ludartin
Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31784199]
PC-3 IC50
7.5 μM
Compound: 1
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
[PMID: 23886685]
PC-3 IC50
7.5 μM
Compound: 1
Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
T98G IC50
6.3 μM
Compound: 1
Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
THP-1 IC50
3.1 μM
Compound: 1
Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay
[PMID: 23886685]
THP-1 IC50
3.1 μM
Compound: 1
Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay
[PMID: 24484897]
Molecular Weight

246.30

Formula

C15H18O3
CAS No.
SMILES

C[C@]12[C@]3([H])[C@]4([H])[C@](CCC(C)=C3C[C@@]1([H])O2)([H])C(C(O4)=O)=C
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ludartin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ludartin36149-87-8ApoptosisGlutathione PeroxidaseStevia yaconensisSprague?Dawley ratsspinal cord injuryInhibitorinhibitorinhibit

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