LY134046

Cat. No.: HY-136625: Ficha de datos Instrucciones de manejo
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LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.

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LY134046 Estructura química

No. CAS : 71274-97-0

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Descripciòn	LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.
Peso molecular	216.11
Fòrmula	C₁₀H₁₁Cl₂N
No. CAS	71274-97-0
SMILES	ClC1=C2C(CCCNC2)=CC=C1Cl
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (268 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Hahn RA, et al. Cardiovascular effects of LY134046, an inhibitor of norepinephrine N-methyltransferase, in spontaneously hypertensive rats. J Pharmacol Exp Ther. 1983 Jul;226(1):39-45. [Content Brief]

LY134046 Related Classifications

Cardiovascular Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY13404671274-97-0LY 134046LY-134046N-myristoyltransferaseNMTInhibitorinhibitorinhibit

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LY134046

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LY134046 Related Classifications

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