Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells

  • Nat Neurosci. 2002 Sep;5(9):831-2. doi: 10.1038/nn911.
Ya Ping Wang  1 ,  Gabriel Dakubo ,  Paul Howley ,  Katrina D Campsall ,  Chantal J Mazarolle ,  Sarah A Shiga ,  Paula M Lewis ,  Andrew P McMahon ,  Valerie A Wallace
Affiliations
  • 1. Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
PMID: 12195432 DOI: 10.1038/nn911
Abstract

The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic Hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina.