2. Academic Validation
  3. Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies

  • J Med Chem. 2006 Feb 9;49(3):1212-6. doi: 10.1021/jm0510373.
Neeraj Mahindroo 1,  Chiung-Chiu Wang,  Chun-Chen Liao,  Chien-Fu Huang,  I-Lin Lu,  Tzu-Wen Lien,  Yi-Huei Peng,  Wei-Jan Huang,  Ying-Ting Lin,  Ming-Chen Hsu,  Chia-Hui Lin,  Chia-Hua Tsai,  John T-A Hsu,  Xin Chen,  Ping-Chiang Lyu,  Yu-Sheng Chao,  Su-Ying Wu,  Hsing-Pang Hsieh
Affiliations

Affiliation

  • 1 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China.
PMID: 16451087 DOI: 10.1021/jm0510373
Abstract

A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPARgamma protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPARgamma protein resulting in potent activity.

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